Cell Killing Regulating Lytic Granule Clustering and NK HkRP3 Is a Microtubule-Binding Protein
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NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing
Natural killer (NK) cell activation triggers sequential cellular events leading to destruction of diseased cells. We previously identified lytic granule convergence, a dynein- and integrin signal-dependent movement of lysosome-related organelles to the microtubule-organizing center, as an early step in the cell biological process underlying NK cell cytotoxicity. Why lytic granules converge duri...
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